Ivermectin Side Effects
All kinds of drugs or medicine may bring side effects. However, many people or pets get no or minor side effects. Please consult your licensed veterinarian if any of these most usual side effects endure or become nettlesome when administering any drugs of which the main ingredient is ivermectin:
Diarrhea, nausea, dizziness.
Please look for medical attention immediately if some of these serious side effects take place when administering ivermectin:
Serious allergic reactions (hives; rash; difficulty breathing; itching; swelling of the lips/face/tongue/mouth; tightness in the chest); swelling, eye pain, or redness; fast heartbeat; fainting; joint pain; fever; red/blistered/swollen/peeling skin; lightheadedness or severe dizziness; seizures, swelling of the arms, ankles, skin, or feet; swollen or tender lymph glands (for instance, underarms, in the neck, groin); yellowing of the skin or eyes; vision changes.
It should be noted that the list above is not a complete list of ivermectin side effects. Should you have further questions about ivermectin side effects, the best recommendation is to contact your doctor or veterinarian or health care provider for more medical advice and information about ivermectin side effects. In order to report ivermectin side effects to the appropriate party, please refer to the Guide to Reporting Problems to FDA.
Ivermectin Side Effects by Body System
As a matter of fact, Ivermectin is considerably tolerated when compared to the other microfilaricidal agents (for instance, diethylcarbamazine, thiabendazole). Some inauspicious reactions (such as fever, myalgia, pruritus, headache) take place generally during the very first 3 days after the administration of the treatment and come out to be associated to the stage of parasitic infection as well as systematic mobilization as well as deteriorating of microfilariae. The bulk of reactions can ordinarily be handled with aspirin, antihistamines and/or acetamiophen. Contrary effects have a tendency to take place with smaller frequency throughout the periods of retreatment.
Ocular side effects, as a matter of fact, have included anterior uveitis, eyelid edema, conjunctivitis, blurred vision, punctate opacity, limbitis, abnormal sensation in the eyes, keratitis, and choroiditis/ chorioretinitis. Nevertheless, these side effects are also related to the aliment onchocerciasis. Also, loss of vision has taken place seldom but generally settled without the treatment of corticosteroid. Conjuctvital hemorrhage has been accounted throughout postmarketing felt in some patients cared for onchocerciasis.
Aggravating of Mazzotti reactions, including lymph node tenderness and enlargement, arthralgia, pruritus, synovitis, skin involvement (including papular and frank urticarial rash or pustular, edema) and fever has been accounted throughout the very first 4 days coming after treatment for onchocerciasis.
There are also nervous system side effects due to using ivermectin. These side effects includes headache, dizziness, somnolence, tremor and vertigo. Severe encephalopathy has been described seldomly in patients with onchocerciases and severely infected with Loa loa, either after treatment with ivermectin or spontaneously. Moreover, seizures have been accounted throughout postmarketing experience.
This type of side effects includes constipation, anorexia, nausea, diarrhea, abdominal distention and vomitting
Other side effects includes fatigue, asthenia, abdominal pain, facial edema, chest discomfort as well as peripheral edema.
Hematologic side effects includes reduced leukocyte count (3%), eosinophilia (3%) and raised hemoglobin (1%). Indeed, Hematomatous swellings related to sustained prothrombin times have been accounted. However, the clinical implication is undefined. Anemia and Leukopenia have been accounted in at least one patient.
Hepatic side effects include increased AST and/or ALT. Eleveated bilirubin, elevated liver enzymes as well as hepatitis have been accounted throughout postmarketing experience.
These side effects include orthostastic hypotension and tachycardia. EKG changes, including flattened T waves, prolonged interval and peaked T waves, have been accounted in one case. Hypotension (mainly orthotastic hypotension) has been accounted during postmarketing experience.
As a matter of fact, Dermatologic side effects include urticaria, rash and pruritus. Toxic epidermal necrolysis as well as Stevens-Johnson syndrome have been accounted throughout postmarketing experience.
Another side effect, the respiratory side effect includes laryngeal edema, worsening bronchial asthma as well as dyspnea.
This type of side effect includes mylagia
Renal side effects include rare transient proteinuria
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